PROLONGED USE OF ANTIBIOTIC IN PREVENTION OF INTRA-AMNIOTIC INFECTIONS IN PRETERM PREMATURE RUPTURE OF MEMBRANES.
DOI:
https://doi.org/10.22370/revmat.1.2025.4126Keywords:
Antibiotic, Intra-amniotic infection, Preterm premature rupture of membranes, ProphylaxisAbstract
Objective: analyze the prolonged use of antibiotics in the prevention of intra-amniotic infections (IAI) in preterm premature rupture of membranes (PPROM).
Material and methods: a review of articles, clinical trials, and books. Using inclusion and exclusion criteria, 21 studies were selected.
Results: antibiotics are widely administered in obstetrics, essential for treating and preventing infections. PPROM occurs as a cause or consequence of IAI due to various pathogens. The benefits of antibiotic use in PPROM include the prevention of IAI, prolongation of the latency period, and reduction of neonatal morbidity. However, consequences such as increased antimicrobial resistance and dysbiosis in both mother and fetus have been observed, so careful antibiotic selection is crucial. The current recommendation is a combination of ceftriaxone, clarithromycin, and metronidazole, showing an increase in the latency period, reduction in chorioamnionitis, adverse neonatal outcomes, and safety for the mother and fetus.
Conclusions: the administration of antibiotics should be rationalized: the evidence shows that while there are benefits to their use in PPROM, risks such as antimicrobial resistance, a major public health issue, cannot be overlooked. Actions should be individualized. This becomes relevant in midwifery to formulate evidence-based clinical standards on antibiotic use in obstetric patients.
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